🫠 This Week in Psychedelics

Welcome to Tricycle Day. We’re the psychedelic newsletter that’s better than an alarm clock. There’s no snooze button, so you’re practically guaranteed to awaken. 👁️

Here’s what we got this week.

• Microdosing LSD improves your sleep 💤

• Colorado’s psychedelic offenders could be pardoned ⛓️‍💥

• Psyence secures its ibogaine supply chain 🚢

• Network with psychedelic professionals 🤝

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MICRODOSES

🔬 Research

Kick the habit: Across 16 studies, psilocybin therapy led to major reductions in alcohol and tobacco use.
Watch your mouth: Speech patterns can reliably predict preparedness for and transformation after 5-MeO-DMT.
Biosynthesize me: Researchers at Miami University broke their own record for highest production of psilocybin to date from a recombinant host.
Beauty matters: Aesthetic enhancements during psychedelic sessions are linked to positive emotional and cognitive shifts.
Share your life review: Participate in the first large-scale study collecting real-world evidence on the safety and effectiveness of ibogaine.

🏛️ Policy

No pain, all ‘gaine: The Texas Ibogaine Initiative has cleared a house committee unanimously. Meanwhile, delegates from 15 states met in Aspen to coordinate ibogaine policy efforts.
Show and tell: Nevada’s Senate passed a joint resolution urging US Congress to reschedule psychedelics, while an Assembly committee approved a bill to create a psychedelic therapy pilot program.
But they were just for research: Florida’s Senate passed a bill that would outlaw psychedelic mushroom spores.
Imagine that: According to a UK government report, drug-related law enforcement is more likely to increase violence than reduce it.
That’s the spirit: More Americans are using psilocybin ever since a wave of decriminalization started in 2019.

📈 Business

Claim your trip: Another Oregon psilocybin service center is taking insurance.
Nail biter: Compass Pathways, which just dosed the last participants in its Phase 3 psilocybin trial, is expected to release results by the end of the quarter.
Blockbuster: Sales of Spravato, J&J’s ketamine spray, are on pace to surpass $1 billion this year.
Power couple: Cybin is partnering with Osmind to prepare for commercialization.
In plain sight: Dozens of illegal mushroom dispensaries are operating across Canada.

🫠 Just for fun

The truth is out there: We found evidence of life on a faraway planet.
Oh the irony: It was an LSD trip that blew up Aldous Huxley’s family.
It is sleek though: The latest “natural psychedelic” is a $10,000 sound bath.
Olo: Scientists claim to have discovered a new, never-before-seen color.
Meme of the week: When you return to Earth after a DMT trip through the multiverse…

THE PEAK EXPERIENCE

Good night, sleep tight

Struggling to get those 8 elusive hours? Maybe your Oura-ring, blue-light-blocker, sound-machine, sheep-counting routine is missing one key component:

A tiny bit of acid.

We know you’re tired, but hear us out. Skeptics have long argued that the benefits of microdosing are just glorified placebo effects, but a new study offers compelling evidence that something measurable and clinically significant is happening at night.

Researchers tracked the sleep patterns of 80 healthy men who microdosed LSD (10 μg every third day) or placebo for six weeks. And the results are eye opening, err, eye shutting?

• 🕰️ More sleep: Participants slept an extra 24.3 minutes on nights following a microdose compared to placebo.

• 😴 Deeper dreams: REM sleep—vital for information processing, emotional regulation, and physical health—increased by 8.1 minutes.

• 🛌 Earlier bedtime: Participants hit the sack about 25 minutes earlier after microdose days.

• ⌛ Delayed effect: No sleep changes (positive or negative) occurred on the dosing day—only the following night.

This isn’t just about sleep, mind you. These findings could at least partially explain why so many microdosers swear they feel less depressed.

See, sleep disturbances are a hallmark of depression. The researchers think that by restoring healthy sleep patterns and promoting synaptic plasticity, microdosing might be addressing an underlying mechanism of mood disorders.

For those tracking the microdosing hype cycle, this research hits different because it measured an objective physiological outcome rather than relying on self-reported benefits. And 24 minutes may not sound like much, but experts agree that’s more than enough to move the needle on health and longevity.

Alright, gotta go. Time for our beauty rest. 🫠

AFTERGLOW

Off the (criminal) record

Call us crazy, but we don’t think anyone should have a criminal record for something that’s no longer illegal. At least a few Colorado lawmakers agree, too, which is why they’re finally addressing this disconnect with a bill that could clear countless psychedelic-related convictions in one fell swoop.

The legislation, introduced by Sen. Matt Ball and Rep. Lisa Feret, would empower Gov. Jared Polis to grant mass pardons to people convicted of possessing psilocybin, mescaline, ibogaine, and DMT—all legal for adults under the state's natural medicine law. To his credit, Polis has been pushing for this authority since 2023.

Think about it. As of now, convictions for mushrooms could be blocking people from jobs in a state where those same mushrooms are the basis of a whole regulated therapy system. Make it make sense (jk, you can’t). Beyond the pardons, the bill would create a data tracking system and simplify the licensing process for healing centers by dropping the fingerprint background checks. Because, right right, natural medicine pioneers are not in fact hardened criminals.

Straight from the source

We still love you, psilocybin, but these days it feels like there’s a new “it molecule” in psychedelic medicine. Psyence BioMed just dropped half a million dollars into PsyLabs, a South African psychedelics manufacturer, essentially calling dibs on the world's first reliable supply of pharmaceutical-grade ibogaine.

The follow-on investment builds on Psyence's existing 11% stake in PsyLabs, who's already hooking Psyence up with GMP-certified, nature-derived (i.e., non-synthetic) psilocybin. But this latest move is all about diversifying their psychedelic portfolio to include ibogaine, a compound derived from the Central African iboga plant, which has gained lots of attention lately for its potential to treat substance use disorders (among other conditions).

It’s the textbook “vertical integration” play, as the LinkedInfluencers might say. Psyence isn’t just playing around in labs and running trials; they’re making sure nobody can cut off their access to medicine. Bold move, but it just might pay off. In the still-weird world of psychedelic biotech, quality compounds are scarce. Controlling your own supply chain could be what separates the real players from the press release pushers.

CYCLISTS’ PICKS

• 📆 Event: The next meeting of the Psychedelic Professionals Networking Club is a special one. Register for $5 with code TRICYCLE.

• 🎧 Podcast: NPR’s Short Wave pod released a three-part series on some of the most interesting questions in psychedelic science.

• 🧢 Dad hat: MAPS dropped some fire merch for Psychedelic Science 2025.

• 📒 Workbook: The Beginner’s Guide to Psychedelics lays out practical and creative exercises to help you turn your insights into lasting change.

UNTIL NEXT TIME

That’s all for today, Cyclists! Whenever you’re ready, here’s how we can help.

ONE CYCLIST’S REVIEW

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DISCLAIMER: This newsletter is for educational and informational purposes only and is not intended as a substitute for professional medical advice. The use, possession, and distribution of psychedelic drugs are illegal in most countries and may result in criminal prosecution.