🫠 This Week in Psychedelics

Welcome to Tricycle Day. 9 out of 10 shamans recommend reading our psychedelics newsletter. Source: trust me, bro.

Here’s what we got this week.

• Psilocybin use in the wild 🍄

• Protecting states’ psychedelic rights 👁️

• Cybin and Fluence collab 🤝

• Sip on some psychedelic water 🥤

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RESEARCH

The world’s largest real-world psilocybin study

There’s no doubt about it. Psychedelic-assisted therapy would improve—even save—countless lives.

The problem is, the clinical model just doesn’t reflect how most people use psychedelics today.

We have a serious accessibility problem. And that’s why the latest study from researchers at Johns Hopkins is so encouraging. In the largest ever prospective survey of naturalistic psilocybin use, they found that taking mushrooms in the “real world” (without a therapist) still led to lasting benefits.

The researchers followed 2,800+ adults before—and up to 3 months after—their (on average, 3.1-gram) mushroom trip. And the results were overwhelmingly positive.

• 😭 42% were depressed before → only 15% were after

• 😰 29% were highly anxious before → only 15% were after

• 🥴 16% abused alcohol before → only 11% did after

• 🫂 50% improved their relationships with others

• 🧑‍💻 27% noticed better performance at work

• 💪 27% started exercising more

• 🍏 24% ate a more nutritious diet

• 😀 94% found the experience beneficial overall

Worth mentioning: having a sitter or guide present was NOT a meaningful predictor of any of these outcomes. But a full-on mystical experience was (and 22% were so lucky). ✨

So if a psychedelic therapist doesn’t fit your budget, no worries. You can’t pay for cosmic intervention, anyway.

MICRODOSES

🌍 David Attenborough not included: Watching nature-themed videos may improve outcomes in psychedelic-assisted therapy for alcohol addiction.

👃 Sniff back from that ledge: In a Phase 2 study, Seelos Therapeutics’ intranasal racemic ketamine spray reduced symptoms of depression in adults at imminent risk of suicide.

🙋 Take away the pain: Researchers at UMich investigating psilocybin as a treatment for fibromyalgia are seeking study volunteers.

💊 Concurrent use: Psilocybin may be effective for treatment-resistant depression, even in people who continue taking SSRIs.

POLICY

Feds, quit meddling with psychedelic-friendly states

So your local government has taken the brave and progressive step to decriminalize psychedelics. Hooray! You can now exercise cognitive liberty without fear of criminal prosecution. 🙌

… or so you thought. Next thing you know, the DEA is busting through your door to lay down the full weight of the federal law. 😱

Okay, okay, relax. It was just a hypothetical. But with more and more US cities and states enacting pro-psychedelic policy reform, it’s certainly not outside the realm of possibility.

Now, avoiding this exact scenario is the reason Congressman Robert Garcia (D-CA) introduced new legislation this week. His 2-page bill would prohibit federal agencies from interfering with states’ own laws on psilocybin.

When he drafted the Validating Independence for State Initiatives on Organic Natural Substances (or VISIONS) Act 2023, Rep. Garcia took a little inspo from cannabis history. He says he copied language directly from similar measures that got the feds to stop enforcing cannabis prohibition, despite the fact that—like psilocybin—it’s still illegal at the federal level, too.

Smart man. Why reinvent the wheel?

MICRODOSES

🆓 Free.99: A new bill proposed in Michigan would legalize psychedelic plants and fungi, as long as people who grow and share them aren’t paid or given anything valuable in return.

👀 The sincerest form of flattery: An Indiana Congresswoman says the state should copy Oregon’s legal psilocybin program if it will help keep Hoosiers alive.

🤷 Toss up: California’s governor, who shared mixed feelings about psychedelics, is still undecided on whether he’ll sign the legalization bill on his desk.

🇪🇺 EuroTrip: The European Medicines Agency (EMA) included psychedelics in its new draft guidelines for depression drug development. They’re taking public comments through March 2024.

BUSINESS

An iconic psychedelic duo emerges

The hottest collab of 2023 just dropped. You mean Ice Spice and Nicki Minaj? Nah. Jonas Brothers and TXT? Get real.

It’s psychedelic powerhouses, Cybin and Fluence, who just joined forces to advance the field of psychedelic therapy. 🫳🎤

So yeah, we wouldn’t recommend holding your breath for a fire mixtape anytime soon. (Sorry.) But there’s still a good reason they’re teaming up.

• 🍄 The situation: Cybin is getting closer to launching a Phase 3 trial of CYB003, its psilocybin analogue, for major depressive disorder.

• 🤔 The problem: They’re gonna need lots of qualified facilitators to run such a massive, global study. Not many exist today.

• 💡 The solution: So they tapped Fluence, a respected (and Oregon-approved) psilocybin training provider, to help select and train facilitators for the research.

Cybin’s been all over the news lately. Last month, they acquired their competitor Small Pharma, creating the psychedelic industry’s largest IP portfolio in the process. Then last week, the billionaire Steve Cohen bought ~19 million shares of the company, signaling to outside investors that psychedelics are a buy.

The big-brain move here is that Cybin is skating where the puck is going. See, it’s not just about the trial. If/when their drug is approved, now there will be a whole crop of freshly certified facilitators ready for showtime.

MICRODOSES

🫂 Empathy skills: TheraPsil, a nonprofit advancing legal access to psychedelics in Canada, is launching an MDMA-assisted psychotherapy training program.

🫀 Default alive: Numinus is cutting costs to fast-track its path to profitability.

💆 Focus, team: Filament and Jaguar Health have formed a joint venture to tackle ADHD and other mental health conditions with plant-derived medicines.

🧑‍💻 Perks of the job: Enthea, a health plan startup, now offers ketamine-assisted therapy as a workplace benefit to employers nationwide.

💰 Don’t spend it all in one place: Clearmind Medicine raised $2.25 million through a public offering to cover operating expenses, R&D, and possibly future acquisitions.

📈 Business is booming: The psychedelic drug market could rip to $7.2 billion by 2029, according to a leading data analytics company.

Psychedelic Water — We’re slightly concerned this drink might become our new obsession. Psychedelic Water’s mood-boosting alcohol alternative now comes in a lightweight powder you can take and (re)mix on the go. The aptly named Good Mood Mix contains psychoactive plants like kava and velvet bean to melt away stress and leave you feeling all warm and fuzzy inside. And since it’s caffeine free, it makes for a great turn-up or wind-down routine. Try it with code TRICYCLEDAY and take 10% off.

Psychedelics 101 — No psychonaut friends? No problem. If you’ve been searching for an online club to hang, connect, and integrate with, The Flying Sage is a great option. They’ve got a free Psychedelic 101 event coming up, where you can expand your knowledge and get a taste for their lively community. You can also snag a self-paced version of the course, plus membership to their community, as a package deal.

1440 Newsletter — When it comes to psychedelic news, we’ve got you covered. But for everything outside our domain—politics, culture, science, finance, even sports—we look to 1440 for the best unbiased news source. (So do 2.7 million other readers.) Because unlike the mainstream media outlets, it has no hidden agenda. They give you just the facts with no spin, so you can make your own informed decisions, all in a quick five-minute read.

That’s all for today. Before you head off, don’t forget to share, rate, and review Tricycle Day below. Catch ya next time, Cyclists! ✌️

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DISCLAIMER: This newsletter is for educational and informational purposes only and is not intended as a substitute for professional medical advice. The use, possession, and distribution of psychedelic drugs are illegal in most countries and may result in criminal prosecution.